Abstract #2264
In-vivo 1 H MRS Shows Increased Liver Choline Levels in Hepatitis C Viral Infection
Nigel Paul Davies 1,2 , Robert Flintham 3 , Reina Lim 4 , and Jeremy W Tomlinson 4
1
Imaging & Medical Physics, University
Hospitals Birmingham NHS Foundation Trust, Birmingham,
West Midlands, United Kingdom,
2
School
of Cancer Sciences, University of Birmingham,
Birmingham, West Midlands, United Kingdom,
3
Imaging
& Medical Physics, University Hospitals Birmingham NHS
Foundation Trust, Birmingham, United Kingdom,
4
University
of Birmingham, Birmingham, United Kingdom
Hepatitis C virus (HCV) is a RNA virus with diverse
genotypes and a broad spectrum of clinical outcome.
Non-invasive methods for assessing disease severity and
predicting treatment response are sought. In-vivo
1
H
MRS at multiple TE with correction for T2 decay has been
used to investigate liver fat and total choline (tCho)
levels in treatment-nave HCV patients with early-stage
liver disease compared with healthy controls. No
significant differences in lipid levels were found. tCho
was significantly higher in the HCV group compared with
the controls. Potential changes in liver choline levels
in HCV after a novel drug treatment will be
investigated.
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