Abstract #2265
31 P MRSI of the healthy liver at 3T and 7T with AMESING-boosted SNR
Jurgen H. Runge 1 , Wybe J.M. van der Kemp 2 , Dennis W.J. Klomp 2 , Aart J. Nederveen 1 , and Jaap Stoker 1
1
Radiology, Academic Medical Center,
Amsterdam, Netherlands,
2
Radiology,
University Medical Center Utrecht, Utrecht, Netherlands
Patients with diffuse hepatic disease (e.g. viral
hepatitis and NASH) may present with liver fibrosis or
inflammation. Preliminary studies indicate that
31
P-MRS
may play a role in the non-invasive determination of
liver inflammation by mapping NADPH concentration. We
compared 2D MRSI at 3T with a SNR optimized 7T set-up
and implemented the adiabatic multi-echo spectroscopic
imaging sequence (AMESING) of the liver at 7T for
further SNR gain. SNR increased by 1.3 to 3.1 between 3T
and 7T while AMESING further boosted SNR by 1.2 to 1.6,
showing its potential for the quantitative mapping of
metabolite concentrations throughout the liver.
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