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Abstract #2266

Liver biopsy, MRS and MRI fat fraction quantification in patients presenting fat and iron overload

Elise Bannier 1 , Amandine Coum 2,3 , Anne Boulic 4 , Giulio Gambarota 2,3 , and Yves Gandon 4

1 Unit VISAGES U746 INSERM-INRIA, IRISA UMR CNRS 6074, University of Rennes, Rennes, France, 2 INSERM, UMR 1099, Rennes, France, 3 Universit de Rennes 1, LTSI, Rennes, France, 4 Radiology Department, University Hospital of Rennes, Rennes, France

The purpose of the present study was to assess the ability of MR spectroscopy to quantify hepatic liver fat overload in the presence of low to moderate iron overload and compare the results with multi gradient echo MR imaging and percutaneous liver biopsy. Multi-spectral fat composition and quantification of saturated and unsaturated fatty acid ratios were also investigated. Fat fraction measurements obtained using MR spectroscopy, imaging and biopsy were well correlated. While MRI allows imaging of the whole liver, MR spectroscopy enables quantification of saturated and unsaturated fatty acid ratios

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