Abstract #2266
Liver biopsy, MRS and MRI fat fraction quantification in patients presenting fat and iron overload
Elise Bannier 1 , Amandine Coum 2,3 , Anne Boulic 4 , Giulio Gambarota 2,3 , and Yves Gandon 4
1
Unit VISAGES U746 INSERM-INRIA, IRISA UMR
CNRS 6074, University of Rennes, Rennes, France,
2
INSERM,
UMR 1099, Rennes, France,
3
Universit
de Rennes 1, LTSI, Rennes, France,
4
Radiology
Department, University Hospital of Rennes, Rennes,
France
The purpose of the present study was to assess the
ability of MR spectroscopy to quantify hepatic liver fat
overload in the presence of low to moderate iron
overload and compare the results with multi gradient
echo MR imaging and percutaneous liver biopsy.
Multi-spectral fat composition and quantification of
saturated and unsaturated fatty acid ratios were also
investigated. Fat fraction measurements obtained using
MR spectroscopy, imaging and biopsy were well
correlated. While MRI allows imaging of the whole liver,
MR spectroscopy enables quantification of saturated and
unsaturated fatty acid ratios
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