Abstract #2270
Evaluation of a selective homonuclear multiple quantum coherence transfer CSI (SelMQC-CSI) sequence for lactate measurement in abdominal tumours
Lisa M Harris 1 , Nina Tunariu 1 , Nandita M deSouza 1 , Sharon Giles 1 , Veronica Morgan 1 , Alison MacDonald 1 , Martin O Leach 1 , and Geoffrey S Payne 1
1
CRUK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research and Royal Marsden Hospital,
Sutton, Surrey, United Kingdom
Lactate is an important metabolite in the assessment of
malignant tissue detectable by magnetic resonance
spectroscopy. It is often difficult to clinically detect
the lactate methyl resonance, as the peak at 1.3 ppm is
frequently obscured by intense lipid resonances. In this
study we have successfully evaluated a selective
homonuclear multiple quantum coherence transfer CSI (SelMQC-CSI)
sequence in a small test group of patients with
abdominal lesions. It was possible to detect and measure
lactate in three patients (mean sd = 16.5 1.7 mM,
not corrected for T1 or T2, CRLB < 1.4) with abdominal
lesions at 1.5T.
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