Abstract #2271
Drug Dissolution: Investigation of Different Fluor Containing Substances using 19 F-MRI
Janet Friedrich 1 , Julia Schrder 1 , Sarah Kindgen 2 , Stefan Fischer 1 , Mark Schuppert 1 , Karsten Gogoll 2 , Peter Langguth 2 , and Laura Maria Schreiber 1
1
Department of Radiology, Johannes Gutenberg
University Medical Center, Mainz, Germany,
2
Institute
of Pharmaceutical Technology and Biopharmacy, Johannes
Gutenberg University, Mainz, Germany
The aim of the present work was the evaluation of
different fluor containing substances in reference to
their MR properties (relaxation times, signal intensity,
spectra) and their potential usage in further
investigations of drug dissolution processes.
Perfluoro-15-crown-5-ether (PFCE), toothpaste jelly and
two fluorinated alkanes were investigated. From MR side
PFCE and SFA2 turned out to be the most attractive
substances among the investigated compounds. However,
the advantageous chemical properties assigned SFA2 as
the most promising compound. Thus, a first tablet loaded
with SFA2 was prepared and imaged.
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