Abstract #2273
Hyperpolarized pyruvate allows early detection of lactate in real-time metabolism of acute liver failure rats
Laia Chavarria 1,2 , Jordi Romero-Gimnez 1,2 , Eva Monteagudo 3 , Juan Crdoba 1,2 , and Silvia Lope-Piedrafita 3,4
1
Liver Unit, Hospital Vall Hebron, Barcelona,
Barcelona, Spain,
2
Centro
de Investigacin Biomdica en Red de Enfermedades
Hepticas y Digestivas (CIBEREHD), Barcelona, Barcelona,
Spain,
3
Servei
de RMN, Universitat Autnoma de Barcelona, Cerdanyola
del Valls, Barcelona, Spain,
4
Centro
de Investigacin Biomdica en Red en Bioingeniera,
Biomateriales y Nanomedicina (CIBER-BBN), Barcelona,
Spain
Intracranial hypertension is a severe complication of
acute liver failure (ALF) secondary to brain edema. The
pathogenesis of cerebral edema in ALF is not clear but
it is known that energy metabolism alterations are
involved where a genesis of lactate seems to have an
important role. We have studied the dynamic synthesis of
brain metabolites using hyperpolarized 1-13C pyruvate in
a rat model of ALF. We have found that ALF rats have a
significant increase in the lactate/pyruvate ratio as
compared to Control rats. Also, the production rate of
lactate and alanine was higher in ALF rats.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
