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Abstract #2274

Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphoedema: An Exploratory Study.

Marco Borri 1 , Maria A. Schmidt 2 , Kristiana D. Gordon 2,3 , Julie Hughes 2 , Erica D. Scurr 2 , Dow-Mu Koh 2 , Peter S. Mortimer 2,3 , and Martin O. Leach 2

1 CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden, Sutton, Surrey, United Kingdom, 2 CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden, Surrey, United Kingdom, 3 Department of Medicine, St George's University of London, London, United Kingdom

Breast cancer-related lymphoedema remains one of the most common and distressing morbidities in breast cancer survivors treated with surgery. In this work we have extended the use of Contrast-Enhanced MR Lymphangiography to upper limbs and produced high resolution MR images of lymphatic vessels at 1.5T. We propose a new quantitative protocol, which employs an intradermal injection with lower concentration of contrast agent and prevents T2*-related signal loss, allowing correct modelling of contrast agent uptake and minimizing venous enhancement. This protocol appears suitable for quantitative studies, and enables both structural and functional evaluation of the lymphatic system within the same examination.

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