Reproducibility and Diffusion Direction Dependence of Helium-3 Lung Morphometry

Lung morphometry with hyperpolarized helium-3 MRI is a highly sensitive technique for the non-invasive measurement of alveolar microstructural parameters. Herein, we establish the reproducibility and diffusion direction dependence of this technique in five healthy subjects. The values of all lung morphometry parameters (including acinar duct radius, alveolar depth, and mean chord length) were highly reproducible over the short and long-term and did not depend upon the direction of the applied diffusion gradient. Together, this provides confidence for the use of helium-3 lung morphometry for longitudinal studies and clinical trials.

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