Abstract #2276
Early Detection Of Smoking-Induced Pulmonary Alterations Using Hyperpolarized 3 He MRI Derived Alveolar Partial Pressure of Oxygen
Hooman Hamedani 1 , Stephen J. Kadlecek 1 , Masaru Ishii 2 , Yi Xin 1 , Hoora Shaghaghi 1 , Biao Han 1 , Sarmad Siddiqui 1 , Sarah Zarrin 3 , Milton Rossman 1 , and Rahim R. Rizi 1
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
Johns
Hopkins University, Merryland, United States,
3
University
of Pennsylvania, PA, United States
While hyperpolarized (HP) gas MRI has been used to
estimate alveolar oxygen tension (
p
A
O
2
)
[1], it has not been systematically compared to Gold
standard to assess its potential for monitoring disease
progression and response to new therapies. In this work,
we compare imaged
p
A
O
2
to
data produced via pulmonary function test, six-minute
walk test, and St.-George Questionnaire.
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