Early Detection Of Smoking-Induced Pulmonary Alterations Using Hyperpolarized 3 He MRI Derived Alveolar Partial Pressure of Oxygen
Hooman Hamedani 1 , Stephen J. Kadlecek 1 , Masaru Ishii 2 , Yi Xin 1 , Hoora Shaghaghi 1 , Biao Han 1 , Sarmad Siddiqui 1 , Sarah Zarrin 3 , Milton Rossman 1 , and Rahim R. Rizi 1
University of Pennsylvania, Philadelphia,
PA, United States,
Hopkins University, Merryland, United States,
of Pennsylvania, PA, United States
While hyperpolarized (HP) gas MRI has been used to
estimate alveolar oxygen tension (
, it has not been systematically compared to Gold
standard to assess its potential for monitoring disease
progression and response to new therapies. In this work,
we compare imaged
data produced via pulmonary function test, six-minute
walk test, and St.-George Questionnaire.
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