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Abstract #2277

In vivo MRI effectively monitors onset and progression of bleomycin-induced lung fibrosis in free-breathing mice

Greetje Vande Velde 1 , Tom Dresselaers 2 , Ellen De Langhe 2,3 , Jennifer Poelmans 2 , Rik Lories 2,3 , and Uwe Himmelreich 2

1 Imaging & Pathology, KU Leuven, Leuven, Flanders, Belgium, 2 KU Leuven, Flanders, Belgium, 3 UZ Leuven, Flanders, Belgium

Longitudinal MRI may enable sensitive assessment of lung fibrosis onset and progression in free-breathing mice, without radiotoxicity concerns or invasive endpoint measurements. We compared the potential of UTE and self-gated MRI with a conventional respiratory triggered pulse sequence to monitor lung fibrosis onset and progression in the bleomycin-induced pulmonary fibrosis mouse model. All three MRI protocols could sensitively visualize and quantify lung disease onset and progression in individual mice. In vivo MRI results correlated strongly with CT and histological readouts for lung fibrosis. MRI is therefore a safe and non-invasive alternative to invasive methods for screening novel anti-fibrotic therapies.

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