Meeting Banner
Abstract #2277

In vivo MRI effectively monitors onset and progression of bleomycin-induced lung fibrosis in free-breathing mice

Greetje Vande Velde 1 , Tom Dresselaers 2 , Ellen De Langhe 2,3 , Jennifer Poelmans 2 , Rik Lories 2,3 , and Uwe Himmelreich 2

1 Imaging & Pathology, KU Leuven, Leuven, Flanders, Belgium, 2 KU Leuven, Flanders, Belgium, 3 UZ Leuven, Flanders, Belgium

Longitudinal MRI may enable sensitive assessment of lung fibrosis onset and progression in free-breathing mice, without radiotoxicity concerns or invasive endpoint measurements. We compared the potential of UTE and self-gated MRI with a conventional respiratory triggered pulse sequence to monitor lung fibrosis onset and progression in the bleomycin-induced pulmonary fibrosis mouse model. All three MRI protocols could sensitively visualize and quantify lung disease onset and progression in individual mice. In vivo MRI results correlated strongly with CT and histological readouts for lung fibrosis. MRI is therefore a safe and non-invasive alternative to invasive methods for screening novel anti-fibrotic therapies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords