Abstract #2278
Imaging Hyperpolarized 129 Xe Uptake in Pulmonary Barrier and Red Blood Cells Using a 3D Radial 1-Point Dixon Approach: Results in Healthy Volunteers and Subjects with Pulmonary Fibrosis
Suryanarayanan S Kaushik 1,2 , Scott H Robertson 2,3 , Matthew S Freeman 2,3 , Craig Rackley 4 , Zackary I Cleveland 2,5 , Mu He 2 , Rohan S Virgincar 1,2 , Kevin T Kelly 6 , William M Foster 4 , Justus E Roos 5 , H Page McAdams 5 , and Bastiaan Driehuys 2,5
1
Biomedical Engineering, Duke University,
Durham, NC, United States,
2
Center
for In Vivo Microscopy, Duke University Medical Center,
Durham, NC, United States,
3
Graduate Program
in Medical Physics, Duke University, Durham, NC, United
States,
4
Pulmonary,
Allergy and Critical Care Medicine, Duke University
Medical Center, Durham, NC, United States,
5
Radiology,
Duke University Medical Center, Durham, NC, United
States,
6
Radiation
Oncology, Duke University Medical Center, Durham, NC,
United States
MRI of dissolved-phase hyperpolarized
129
Xe
has emerged as a non-invasive probe of gas-exchange in
the lung. Through dissolved-phase spectroscopy resolving
the 197 ppm barrier tissue and 217 ppm red blood cells
(RBC) resonances, we have shown that subjects with
pulmonary fibrosis (PF) display a dramatically reduced
RBC signal, indicative of diffusion limitation. Here, we
show the initial results in creating separate images of
129
Xe
in the barrier tissue and the RBCs, using a 3D 1-pt
Dixon approach. Preliminary application of the technique
to PF now reveals diffusion impairment regionally.
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