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Abstract #2279

Establishing Biomarkers of Gas-Transfer Using Hyperpolarized 129 Xe Dissolved-Phase Spectroscopy in Healthy Volunteers and Subjects with Pulmonary Fibrosis

Suryanarayanan S Kaushik 1,2 , Matthew S Freeman 2,3 , Craig Rackley 4 , Jane Stiles 4 , William M Foster 4 , Justus E Roos 5 , H Page McAdams 5 , and Bastiaan Driehuys 2,5

1 Biomedical Engineering, Duke University, Durham, NC, United States, 2 Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 3 Graduate Program in Medical Physics, Duke University, Durham, NC, United States, 4 Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, United States, 5 Radiology, Duke University Medical Center, Durham, NC, United States

When inhaled, the moderate solubility of hyperpolarized (HP) 129 Xe gives rise to two distinct resonances, in the barrier tissue and plasma (197 ppm) and in the RBC (217 ppm). This dissolved-phase of HP 129 Xe has emerged as a non-invasive probe of pulmonary gas-transfer. While the current gold-standard to measure gas-transfer is DL CO , it is highly variable, and requires good subject compliance. In this work, we use HP 129 Xe spectroscopy as a global biomarker of pulmonary gas-transfer, establish its baseline value in healthy subjects and show that it is dramatically reduced in subjects with pulmonary fibrosis.

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