Meeting Banner
Abstract #2281

Comparison of Pulmonary 1 H non-contrast and Hyperpolarized 3 He MRI Ventilation Abnormalities in Bronchiectasis and COPD

Dante P Capaldi 1,2 , Fumin Guo 1,3 , Sarah Svenningsen 1,2 , Weijing Ma 1,2 , Khadija Sheikh 1,2 , Roya Etemad-Rezai 1 , Jonathon Leipsic 4 , Harvey O Coxson 4 , David G McCormack 5 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Graduate Program in Biomedical Engineering, The University of Western Ontario, London, Ontario, Canada, 4 Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada, 5 Department of Medicine, The University of Western Ontario, London, Ontario, Canada

Free-breathing non-contrast enhanced 1 H MRI ventilation imaging using Fourier decomposition has not yet been optimized at 3T or in patients with severe chronic obstructive pulmonary disease (COPD) or bronchiectasis in whom there are both airway and parenchymal abnormalities. Our objective was to compare FDMRI with hyperpolarized 3He MRI to visualize pulmonary ventilation abnormalities in subjects with bronchiectasis and COPD. Thirty subjects were evaluated using hyperpolarized 3 He MRI and FDMRI of the dynamic free tidal-breathing MRI acquired over two minutes. There was excellent spatial correlation between ventilation defects visualized using both MR methods.

This abstract and the presentation materials are available to members only; a login is required.

Join Here