Abstract #2283
Multi-Nuclear MR Imaging of Ventilation and Perfusion Distribution Response to Bronchodilator in Asthma
Helen Marshall 1 , Steven Thomas 2 , Juan Parra-Robles 1 , Salman Siddiqui 3 , Richard Kay 4 , Chris E Brightling 3 , and Jim M Wild 1
1
Academic Radiology, University of Sheffield,
Sheffield, United Kingdom,
2
Medical
Physics, British Columbia Cancer Agency, British
Columbia, Canada,
3
Institute
for Lung Health, University of Leicester, United
Kingdom,
4
Novartis
Pharma AG, Basel, Switzerland
Ventilation (V) and perfusion (Q) matching is essential
for efficient gas exchange in the lung. Here ventilation
and perfusion distributions were imaged at baseline and
post-bronchodilator in 5 patients with asthma using
3
He
ventilation and
1
H
dynamic-contrast-enhanced perfusion MRI. Maps of
ventilation, peak perfusion and time-to-peak perfusion
were generated and VQ distribution histograms were
plotted. Individual patient VQ response to
bronchodilator differed but tended towards increased and
more homogeneous ventilation and perfusion
post-bronchodilator. Multi-nuclear MRI provided high
resolution images of regional ventilation and perfusion
distributions, and was sensitive to changes in V and Q
following bronchodilator administration in asthmatic
patients.
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