Abstract #2284
Longitudinal Study of Pulmonary Ventilation with 3 He MRI in Asthma Patients
Robert V Cadman 1 , David G Mummy 2 , Scott K Nagle 1,3 , Nizar N Jarjour 4 , Mark L Schiebler 3 , Ronald L Sorkness 5 , and Sean B Fain 1,3
1
Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States,
2
Biomedical
Engineering, University of Wisconsin-Madison, Madison,
WI, United States,
3
Radiology, University of
Wisconsin-Madison, WI, United States,
4
Department
of Medicine, University of Wisconsin-Madison, Madison,
WI, United States,
5
School
of Pharmacy, University of Wisconsin-Madison, Madison,
WI, United States
Although ventilation defects are a significant feature
of
3
He
MRI images of asthmatic lungs, the relationship of those
defects to clinical symptoms of asthma is not well
understood. Using longitudinal
3
He
MRI data, ventilation defects were classified into
categories based on their behavior over time. This
approach will be useful in characterizing the emergence,
reversal, and persistence of such defects in asthmatic
patients. Further studies will investigate the
relationship between emergent ventilation defects and
sites of new airway injury.
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