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Abstract #2286

Assessment of Cystic Fibrosis in Pediatric Subjects using Hyperpolarized Xenon-129 MRI: Regional Mapping of Gas Uptake by Lung Tissue and Blood

Kun Qing 1 , Kai Ruppert 1,2 , Tally A. Altes 1 , G. Wilson Miller 1 , Yun Jiang 3 , Jaime F. Mata 1 , Yun M. Shim 1 , Chengbo Wang 1 , Steven Guan 1 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and John P. Mugler 1

1 University of Virginia, Charlottesville, VA, United States, 2 Cincinnati Children's Hospital, Cincinnati, OH, United States, 3 Case Western Reserve University, Cleveland, OH, United States, 4 Xemed LLC, Durham, NH, United States, 5 University of New Hampshire, Durham, NH, United States

As a non-invasive MR imaging method, 3-D Xe129 dissolved-phase imaging is particularly suited to monitoring functional changes of the lung and evaluating treatment efficacy for CF subjects, especially those in the pediatric population. In this study, we investigated functional changes in 5 pediatric subjects with CF, as compared with young healthy subjects. All tissue-to-gas ratio maps were inhomogeneous, interestingly, for all CF subjects imaged, the average tissue-to-gas ratios were higher in the right lung than the left lung , and most showed lower tissue-to-gas ratios in the right upper lobe as compared to the other lobes in the right lung.

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