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Abstract #2287

Regional Quantification of Lung Function in Cystic Fibrosis using 3D Single-Breath CSI

Steven Guan 1 , Kun Qing 1 , Talissa Altes 1 , John Mugler III 1 , Carolina Fernandes 1 , Kai Ruppert 1 , Iulian Ruset 2,3 , F. William Hersman 2,3 , Deborah Froh 1 , William Teague 1 , Grady Miller 1 , James Brookeman 1 , and Jaime Mata 1

1 University of Virginia, Charlottesville, VA, United States, 2 University of New Hampshire, Durham, NH, United States, 3 Xemed, LLC, Durham, NH, United States

Cystic-fibrosis (CF) is the most common, fatal, gene defect in the Caucasian population. For diseases like CF that have both obstructive and restrictive characteristics, standard pulmonary function tests can only provide a limited global assessment of ventilation parameters. 3D-Single-Breath Chemical-Shift-Imaging (3DSB-CSI) is capable of non-invasively assessing regional ventilation and multiple compartment gas uptake/exchange, which permits a better understanding of the disease and treatment efficacy. The tissue/RBC ratio maps reveal that CF subjects had a higher average tissue/RBC ratio and standard deviation, 2.960.74, compared to that of healthy subjects, 2.390.53(p=0.029). There also appears to be a good correlation (R=0.71) between the tissue/RBC ratio with the predicted FEV1. This pilot clinical study has demonstrated that 3D-SB-CSI is capable of assessing regional ventilation and multiple compartment gas uptake/exchange.

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