Abstract #2287
Regional Quantification of Lung Function in Cystic Fibrosis using 3D Single-Breath CSI
Steven Guan 1 , Kun Qing 1 , Talissa Altes 1 , John Mugler III 1 , Carolina Fernandes 1 , Kai Ruppert 1 , Iulian Ruset 2,3 , F. William Hersman 2,3 , Deborah Froh 1 , William Teague 1 , Grady Miller 1 , James Brookeman 1 , and Jaime Mata 1
1
University of Virginia, Charlottesville, VA,
United States,
2
University
of New Hampshire, Durham, NH, United States,
3
Xemed,
LLC, Durham, NH, United States
Cystic-fibrosis (CF) is the most common, fatal, gene
defect in the Caucasian population. For diseases like CF
that have both obstructive and restrictive
characteristics, standard pulmonary function tests can
only provide a limited global assessment of ventilation
parameters. 3D-Single-Breath Chemical-Shift-Imaging
(3DSB-CSI) is capable of non-invasively assessing
regional ventilation and multiple compartment gas
uptake/exchange, which permits a better understanding of
the disease and treatment efficacy. The tissue/RBC ratio
maps reveal that CF subjects had a higher average
tissue/RBC ratio and standard deviation, 2.960.74,
compared to that of healthy subjects,
2.390.53(p=0.029). There also appears to be a good
correlation (R=0.71) between the tissue/RBC ratio with
the predicted FEV1. This pilot clinical study has
demonstrated that 3D-SB-CSI is capable of assessing
regional ventilation and multiple compartment gas
uptake/exchange.
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