Abstract #2288
Imaging of Structural and Functional Changes in Early Stage CF with 3 He MRI, 1 H MRI and CT
Helen Marshall 1 , David Hughes 2 , Felix Horn 1 , Juan Parra-Robles 1 , Alex Horsley 3 , Laurie Smith 2 , Leanne Armstrong 1 , Ina Aldag 2 , Chris Taylor 2 , and Jim M Wild 1
1
Academic Radiology, University of Sheffield,
Sheffield, United Kingdom,
2
Sheffield
Children's Hospital, Sheffield, United Kingdom,
3
Manchester
Adult CF Centre, University of Manchester, Manchester,
United Kingdom
Early detection of lung disease is vital for effective
treatment of cystic fibrosis. This study investigated
the relative sensitivity of
3
He
ventilation MRI,
1
H
anatomical MRI and CT for detection of early stage lung
disease in children with mild CF. 7 CF patients with
normal spirometry and 5 healthy controls were studied.
Abnormalities were detected in the
3
He
MR and CT images of 6 patients, and the
1
H
MR images of 3 patients.
3
He
MRI and CT provide complementary information about lung
structure and function, and are more sensitive to early
ventilation changes than
1
H
MRI in mild CF.
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