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Abstract #2288

Imaging of Structural and Functional Changes in Early Stage CF with 3 He MRI, 1 H MRI and CT

Helen Marshall 1 , David Hughes 2 , Felix Horn 1 , Juan Parra-Robles 1 , Alex Horsley 3 , Laurie Smith 2 , Leanne Armstrong 1 , Ina Aldag 2 , Chris Taylor 2 , and Jim M Wild 1

1 Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2 Sheffield Children's Hospital, Sheffield, United Kingdom, 3 Manchester Adult CF Centre, University of Manchester, Manchester, United Kingdom

Early detection of lung disease is vital for effective treatment of cystic fibrosis. This study investigated the relative sensitivity of 3 He ventilation MRI, 1 H anatomical MRI and CT for detection of early stage lung disease in children with mild CF. 7 CF patients with normal spirometry and 5 healthy controls were studied. Abnormalities were detected in the 3 He MR and CT images of 6 patients, and the 1 H MR images of 3 patients. 3 He MRI and CT provide complementary information about lung structure and function, and are more sensitive to early ventilation changes than 1 H MRI in mild CF.

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