REVISITING THE 129 XE RELAXATION RATE IN HUMAN BLOOD AND QUANTIFYING THE RELAXIVITY OF DEOXYHAEMOGLOBIN IN THE PRESENCE OF 129 XE
Graham Norquay 1 , General Leung 1 , Neil J Stewart 1 , Gillian M Tozer 2 , Jan Wolber 1,3 , and Jim M Wild 1
Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom,
University of Sheffield, South Yorkshire, United
Healthcare, Amersham, Buckinghamshire, United Kingdom
In this study, the
relaxation rate in human blood was evaluated over a
large range of blood oxygenations (sO2 = 0.02 to 1.00).
relaxation rate (R
) in red blood cells was
found to vary linearly as a function of blood
oxygenation, where the mechanism believed to be
responsible is Xe interactions with paramagnetic
deoxyhaemoglobin. A linear fit of
the concentration of deoxyhaemoglobin ([dHb]) yielded a
Xe relaxivity of 0.035 mM
This linear relationship may be utilised in future
studies involving Xe transport from the lungs to distal
tissues, organs and tumours.
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