Abstract #2292
REVISITING THE 129 XE RELAXATION RATE IN HUMAN BLOOD AND QUANTIFYING THE RELAXIVITY OF DEOXYHAEMOGLOBIN IN THE PRESENCE OF 129 XE
Graham Norquay 1 , General Leung 1 , Neil J Stewart 1 , Gillian M Tozer 2 , Jan Wolber 1,3 , and Jim M Wild 1
1
Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom,
2
Oncology,
University of Sheffield, South Yorkshire, United
Kingdom,
3
GE
Healthcare, Amersham, Buckinghamshire, United Kingdom
In this study, the
129
Xe
relaxation rate in human blood was evaluated over a
large range of blood oxygenations (sO2 = 0.02 to 1.00).
The
129
Xe
relaxation rate (R
1
) in red blood cells was
found to vary linearly as a function of blood
oxygenation, where the mechanism believed to be
responsible is Xe interactions with paramagnetic
deoxyhaemoglobin. A linear fit of
129
Xe
R
1
vs
the concentration of deoxyhaemoglobin ([dHb]) yielded a
dHb-
129
Xe relaxivity of 0.035 mM
-1
s
-1
.
This linear relationship may be utilised in future
studies involving Xe transport from the lungs to distal
tissues, organs and tumours.
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