Abstract #2295
In-vivo Magnetization Transfer Imaging of Mouse Lungs using a Zero Echo Time Sequence at 4.7 T initial Experience.
Moritz C Wurnig 1 , Mingming Wu 2 , Wolfgang Jungraithmayr 3 , Markus Weiger 4 , Klaas P Pruessmann 2 , and Andreas Boss 1
1
Institute of Diagnostic and Interventional
Radiology, University Hospital Zurich, Zurich, Zurich,
Switzerland,
2
Institute
for Biomedical Engineering, University and Swiss Federal
Institute of Technology Zurich, Zurich, Zurich,
Switzerland,
3
Division
of Thoracic Surgery, University Hospital Zurich, Zurich,
Zurich, Switzerland,
4
Institute
for Biomedical Engineering, University and Swiss Federal
Institute of Technology Zurich, Zurich, Zurich, Zurich,
Switzerland
Magnetization transfer (MT) imaging of the lung is
hampered by low spin-density and fast signal decay. Here
we present our initial experience with zero echo time
(ZTE) imaging with a MT preparation pulse applied for
pulmonary MT imaging in-vivo. Experimental MTR values of
non-pulmonary tissues obtained with ZTE showed the
typical characteristics known from conventional MT
sequences. Lung tissue itself showed MTR values between
fatty tissue and liver-tissue. We could show that
measuring MT in the lung in-vivo is feasible and that MT
of lung tissue remains measurable even when large
off-resonance frequencies are used to avoid direct
saturation effects.
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