Abstract #2294
In vivo observations of radiation damping effects from tissue-dissolved hyperpolarized 129Xe
Rosa Tamara Branca 1,2 , Le Zhang 3 , and Carlos Floyd 4
1
Physics and Astronomy, University of North
Carolina at Chapel Hill, Chapel Hill, NC, United States,
2
Biomedical
Research Imaging Center, Chapel Hill, NC, United States,
3
Material
Science, University of North Carolina at Chapel Hill,
NC, United States,
4
Physics
and Astronomy, University of North Carolina at Chapel
Hill, NC, United States
The low gyromagnetic ratio of xenon, the relatively low
polarizability and concentration achievable in distal
organs upon HP-129Xe gas inhalation suggest that in in
vivo settings the observation of radiation damping is
highly unlikely. Nonetheless we report the first
observation of radiation damping effects from
tissue-dissolved hyperpolarized xenon and a revision of
the xenon uptake model to account for the strong local
xenon uptake that leads to the observation of these
effects.
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