Quantification of CPMG relaxation rate in MRI of lung tissue
Felix Tobias Kurz 1 , Thomas Kampf 2 , Sabine Heiland 1 , Martin Bendszus 1 , Heinz-Peter Schlemmer 3 , and Christian Herbert Ziener 3
Division of Neuroradiology, University of
Heidelberg, Heidelberg, Baden-Wrttemberg, Germany,
Physics 5, University of Wuerzburg, Wuerzburg, Bavaria,
German Cancer Research Center, Heidelberg,
Recently, it has been shown that transverse relaxation
rates for Carr-Purcell-Meiboom-Gill (CPMG) sequences in
MRI are dependent on interpulse delay time in lung
tissue. Here, a symmetry-bound physical model to
describe alveolar structure is used within a well-known
weak field approximation to provide an expression for
transverse relaxation rate that is dependent on
interpulse delay time, diffusion, alveolar radius and
volumetric ratio of pulmonal air and blood volume.
Theoretical results are in good agreement with
experimental data for excised rat lung tissue and may be
applied to determine in-vivo lung perfusion parameters
in intravoxel incoherent motion models or to quantify
structural parameters in lung micropathology.
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