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Abstract #2345

Real-time Monitoring of Focused Ultrasound Inertial Cavitationon on Microbubbles by Gradient Echo MRI

Chen-Hua Wu 1 , Chih-Kuang Yeh 1 , Chung-Hsin Wang 1 , Shih-Tsung Kang 1 , Wen-Shiang Chen 2,3 , and Hsu-Hsia Peng 1

1 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2 Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, 3 Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan

In this study, a gradient echo based sequence was used to observe the signal intensity (SI) changes during FUS cavitation for in vitro gel phantom experiments. We investigated SI changes under different concentrations of MBs, FUS powers, and imaging slice thicknesses. Even with conditions of diluted MBs of 0.001X, low FUS power of 2W in a burst mode, or thicker slice of 8 mm, reduced SI still can be observed. The pulse sequence of gradient echo has been proved to be a useful technique for real-time monitoring of SI changes when transmitting FUS to MBs.

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