Abstract #2365
MICROVASCULAR OBSTRUCTION INHIBITS INFARCT HEALING AND ENHANCES COMPENSATORY VENTRICULAR HYPERTROPHY: EXPERIMENTAL CARDIAC MRI STUDY
Maythem Saeed 1 , Hisham Z. Bajwa 1 , Loi Do 1 , Mohammed SA Suhail 1,2 , Steve W. Hetts 1 , and Mark W. Wilson 1
1
Radiology and Biomedical Imaging, University
of California, San Francisco, San Francisco, California,
United States,
2
Radiology,
University of California, San Diego, San Diego,
California, United States
Clinical trials suggest microvascular obstruction (MVO)
portends a poor prognosis and is independent of infarct
size. We aimed to provide evidence that MVO inhibits
infarct healing and enhances compensatory LV
hypertrophy. Cine and DE-MRI was performed in animals
with major and minor MVO. Cine MRI showed that animals
with major and persistent MVO have larger infarct mass
and remote hypertrophied myocardium compared with
animals with minor MVO. MVO caused greater and
persistent decline in ejection fraction and increase in
LV volumes compared with animals with minor MVO. MRI
illustrates that MVO inhibits infarct healing,
accentuates LV hypertrophy/dysfunction.
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