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Abstract #2366

Quantification of L-type Calcium Channel Activity by Manganese-Enhanced MRI in Murine Hearts in Vivo

Kai Jiang 1,2 , Wen Li 1,2 , Raymond F. Muzic 1,3 , and Xin Yu 1,3

1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States, 2 Case Medical Center, Case Western Reserve University, Cleveland, Ohio, United States, 3 Department of Radiology, Case Western Reserve University, Cleveland, Ohio, United States

In this study, a fast T 1 mapping method was proposed for quantification of both the arterial input function and the kinetics of Mn 2+ uptake in mouse myocardium in manganese-enhanced MRI (MEMRI) studies. A compartment model was developed for in vivo estimation of Mn 2+ uptake and efflux rates by fitting the model to MEMRI data.

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