Abstract #2370
Evaluation of the feasibility to use novel tissue engineered grafts for right ventricular outflow tract reconstruction by magnetic resonance imaging
Dagmar Hartung 1 , Serghei Cebotari 2 , Igor Tudorache 2 , Karolina Theodoridis 2 , Tanja Meyer 2 , Alexandru Mogaldea 2 , Robert Ramm 3 , Katja Hueper 1 , Frank Wacker 1 , Andres Hilfiker 3 , and Axel Haverich 2
1
Radiology, Hannover Medical School,
Hannover, Germany,
2
Division
of Cardiothoracic, Transplantation, and Vascular
Surgery, Hannover Medical School, Hannover, Germany,
3
Leibniz
Research Laboratory for Biotechnology and Artificial
Organs, Hannover Medical School, Hannover, Germany
In various congenital heart diseases reconstruction of
the right ventricular outflow tract (RVOT) is necessary.
Pericardium is the currently used material. To improve
longterm graft survival new approaches based on
regenerative medicine are being developed. We evaluated
the feasibility of a novel tissue engineered (TE) graft
composed of an allogeneic TE valve combined with an
autologous vascularized patch of small intestine
(AutoVaM) for RVOT-reconstruction in pigs by MRI. A
graft consisting of a TE valve combined with a
pericardial patch served as control. Morphological and
functional properties of the new AutoVaM-graft were
superior to the conventional pericardial graft for
RVOT-reconstruction.
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