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Abstract #2371

Evaluation of cardiac function in cancer patients by wall motion kinetics using cine cardiac MRI: A feasability study

George Gentchos 1 , Caitlin Baran 2 , Michael Toth 3,4 , Hirak Der-Torossian 5 , Marion Couch 5 , and Kim Dittus 6

1 Radiology, University of Vermont, Burlington, VT, United States, 2 College of Medicine, University of Vermont, Burlington, Vermont, United States, 3 Department of Medicine, University of Vermont, Burlington, Vermont, United States, 4 Molecular Physiology and Biophysics, University of Vermont, Vermont, United States, 5 Surgery, University of Vermont, Burlington, Vermont, United States, 6 Medicine, University of Vermont, Burlington, Vermont, United States

Skeletal muscle dysfunction has been demonstrated by our group in patients with cancer. It is theorized that prolongation of myosin-actin relaxation time may cause diastolic dysfunction. Patients in this cohort underwent cardiac MRI for assessment of LV function using VEC-MRI, however we are exploring a novel technique using wall motion kinetics using semi-automated volumetric analysis to assess systolic and diastolic function. Our study shows good correlation with VEC-MRI of decreased rate of early diastolic filling (passive relaxation) as a marker of diastolic dysfunction. Additionally, our study suggests subtle abnormalities in systolic function using this technique despite preserved global LV function. This technique is simpler and quicker to analyze than VEC-MRI for evaluation of diastolic dysfunction.

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