Abstract #2371
Evaluation of cardiac function in cancer patients by wall motion kinetics using cine cardiac MRI: A feasability study
George Gentchos 1 , Caitlin Baran 2 , Michael Toth 3,4 , Hirak Der-Torossian 5 , Marion Couch 5 , and Kim Dittus 6
1
Radiology, University of Vermont,
Burlington, VT, United States,
2
College
of Medicine, University of Vermont, Burlington, Vermont,
United States,
3
Department
of Medicine, University of Vermont, Burlington, Vermont,
United States,
4
Molecular
Physiology and Biophysics, University of Vermont,
Vermont, United States,
5
Surgery,
University of Vermont, Burlington, Vermont, United
States,
6
Medicine,
University of Vermont, Burlington, Vermont, United
States
Skeletal muscle dysfunction has been demonstrated by our
group in patients with cancer. It is theorized that
prolongation of myosin-actin relaxation time may cause
diastolic dysfunction. Patients in this cohort underwent
cardiac MRI for assessment of LV function using VEC-MRI,
however we are exploring a novel technique using wall
motion kinetics using semi-automated volumetric analysis
to assess systolic and diastolic function. Our study
shows good correlation with VEC-MRI of decreased rate of
early diastolic filling (passive relaxation) as a marker
of diastolic dysfunction. Additionally, our study
suggests subtle abnormalities in systolic function using
this technique despite preserved global LV function.
This technique is simpler and quicker to analyze than
VEC-MRI for evaluation of diastolic dysfunction.
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