Abstract #2396
Myocardial Function and Remodeling in a Baboon Model of Intrauterine Growth Restriction
Geoffrey David Clarke 1 , Jinqi Li 2 , Cun Li 3 , and Peter W Nathanielsz 4
1
Radiology, Univ Texas Health Science Center,
San Antonio, TX, United States,
2
Research
Imaging Institute, Univ Texas Health Science Center, San
Antonio, TX, United States,
3
Obstetrics
& Gynelocogy, Univ Texas Health Science Center, San
Antonio, TX, United States,
4
Obstetrics
& Gynecology, Univ Texas Health Science Center, San
Antonio, TX, United States
In this study cardiac MRI was used to measure LV cardiac
function and 3D sphericity index (3DSI) in 8 male
baboons subjected to intrauterine growth restriction to
determine if subclinical functional impairment and
myocardial remodeling associated with fetal programming
occurs. LV 3DSI in growth restricted animals (N=4) was
significantly different (p=0.03) compared to 3DSI in
age-matched controls (N=5) suggesting myocardial
remodeling does occur in these young animals.
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