Cardiac Lipid Accumulation and Hypertrophy in a Murine Model of Non-alcoholic Fatty Liver
Ulrich Flgel 1 , Tomas Jelenik 2 , Jrg Kotzka 2 , Michael Roden 2,3 , Jrgen Schrader 1 , and Julia Szendroedi 2,3
Molecular Cardiology, Heinrich Heine
University, Dsseldorf, NRW, Germany,
for Clinical Diabetology, German Diabetes Center,
Dsseldorf, NRW, Germany,
Endocrinology & Diabetology & Metabolic Diseases, German
Diabetes Center, Dsseldorf, NRW, Germany
The present study investigated how non-alcoholic fatty
liver (NAFL) and insulin resistance relate to all-over
body lipid homeostasis and cardiac function using
transgenic mice with adipose tissue-specific
overexpression of the transcription factor SREBP-1c.
Analysis of body fat and heart function by
MRI and localized
MRS at 9.4 T revealed that in this model NAFL and
insulin resistance associate with pronounced
lipodystrophy and left ventricular hypertrophy. Although
heart function remained still intact in this setting,
long-term increased cardiac lipids and oxidative stress
are likely to render the heart vulnerable for ischemic
intolerance and impaired myocardial function with age.
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