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Abstract #2397

Cardiac Lipid Accumulation and Hypertrophy in a Murine Model of Non-alcoholic Fatty Liver

Ulrich Flgel 1 , Tomas Jelenik 2 , Jrg Kotzka 2 , Michael Roden 2,3 , Jrgen Schrader 1 , and Julia Szendroedi 2,3

1 Molecular Cardiology, Heinrich Heine University, Dsseldorf, NRW, Germany, 2 Institute for Clinical Diabetology, German Diabetes Center, Dsseldorf, NRW, Germany, 3 Department of Endocrinology & Diabetology & Metabolic Diseases, German Diabetes Center, Dsseldorf, NRW, Germany

The present study investigated how non-alcoholic fatty liver (NAFL) and insulin resistance relate to all-over body lipid homeostasis and cardiac function using transgenic mice with adipose tissue-specific overexpression of the transcription factor SREBP-1c. Analysis of body fat and heart function by 1 H MRI and localized 1 H MRS at 9.4 T revealed that in this model NAFL and insulin resistance associate with pronounced lipodystrophy and left ventricular hypertrophy. Although heart function remained still intact in this setting, long-term increased cardiac lipids and oxidative stress are likely to render the heart vulnerable for ischemic intolerance and impaired myocardial function with age.

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