Abstract #2420
Microvascular obstruction is associated with greater extracellular matrix remodelling in the remote myocardium after infarction: A T1-mapping study
Venkat Ramanan 1 , Mohammad Zia 2 , Idan Roifman 1 , Bradley H Strauss 1 , Kim Connelly 3 , Graham A Wright 1,4 , and Nilesh Ghugre 1,4
1
Physical Sciences Platform, Sunnybrook
Research Institute, Toronto, Ontario, Canada,
2
Toronto
East General Hospital, Toronto, Ontario, Canada,
3
St
Michaels Hospital, Toronto, Ontario, Canada,
4
Department
of Medical Biophysics, University of Toronto, Toronto,
Ontario, Canada
Prior studies have shown that extracellular matrix
alterations can occur both in infarcted and remote
myocardium. However, the relationship between the
extracellular volume (ECV) measurements and the severity
of infarct has not been explored. Here, we investigate
the impact of microvascular obstruction (MVO) on ECV
alterations using MOLLI based T1-mapping. We scanned
patients post-MI at 48 hour and at 3 weeks. We found
that for patients with MVO, ECV was higher significantly
in both infarcted and remote tissue at 3 weeks. These
findings also suggest that early changes in the remote
myocardium may potentially be indicative of long-term
adverse remodeling post-AMI.
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