Meeting Banner
Abstract #2427

In vivo 3D High Resolution Cardiac Diffusion Weighted MRI using Motion Compensated Diffusion-prepared Balanced Steady-State Free Precession Approach: Preliminary Application in Hypertrophic Cardiomyopathy Patients

Christopher Nguyen 1,2 , Zhaoyang Fan 1 , Behzad Sharif 1 , Yi He 3 , Tianjing Zhang 4 , Jing An 4 , Xiaoming Bi 5 , Minjie Lu 6 , Rohan Dharmakumar 1 , Daniel S Berman 1 , Shihua Zhao 6 , and Debiao Li 1,2

1 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 3 Radiology, Anzhen Hospital, Beijing, China, 4 MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, 5 MR R&D, Siemens Healthcare, Los Angeles, CA, United States, 6 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China

Myocardial tissue microstructure exhibits fiber disarray that manifests in a stark increase (50-100% change for 20-70% fibrosis) in trace apparent diffusion coefficient (trADC). To ensure sensitivity to this change, we developed a free-breathing bulk motion compensated diffusion-prepared segmented balanced steady-state free precession technique capable of 3D high resolution in vivo cardiac diffusion-weighted MRI. In healthy volunteers, the proposed technique yielded LV trADC values consistent with previously reported values. Preliminary application in HCM patients revealed 40% increase in trADC in corresponding LGE-identified fibrotic regions. The proposed diffusion technique may potentially allow for non-contrast imaging of myocardial fibrosis in HCM patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here