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Abstract #2428

UTE-based Reflection Point analysis for early diagnosis of infected cardiac valves in mice

Verena Hoerr 1 , Nina Nagelmann 1 , Janine Ring 1 , Arno Nauerth 2 , Michael Kuhlmann 3 , and Cornelius Faber 1

1 Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany, 2 Bruker BioSpin MRI GmbH, Ettlingen, Germany, 3 European Institute for Molecular Imaging (EIMI), Muenster, Germany

In our study we have developed a novel MRI tool kit for the detection of infective endocarditis in mice. It allows for early diagnosis and detailed characterization of morphological and functional changes of infected cardiac valves. By Reflection Point analysis the valvular structures in self-gated cine UTE images are highlighted by rescaling the image intensities according to the distance to the Reflection Point. This corrects for partial volume effects and signal gradients caused by surface coils and allows for an accurate assessment of the cardiac valves during the full cardiac cycle with respect to valve thickening and bacterial vegetations.

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