Abstract #2428
UTE-based Reflection Point analysis for early diagnosis of infected cardiac valves in mice
Verena Hoerr 1 , Nina Nagelmann 1 , Janine Ring 1 , Arno Nauerth 2 , Michael Kuhlmann 3 , and Cornelius Faber 1
1
Department of Clinical Radiology, University
Hospital Muenster, Muenster, Germany,
2
Bruker
BioSpin MRI GmbH, Ettlingen, Germany,
3
European
Institute for Molecular Imaging (EIMI), Muenster,
Germany
In our study we have developed a novel MRI tool kit for
the detection of infective endocarditis in mice. It
allows for early diagnosis and detailed characterization
of morphological and functional changes of infected
cardiac valves. By Reflection Point analysis the
valvular structures in self-gated cine UTE images are
highlighted by rescaling the image intensities according
to the distance to the Reflection Point. This corrects
for partial volume effects and signal gradients caused
by surface coils and allows for an accurate assessment
of the cardiac valves during the full cardiac cycle with
respect to valve thickening and bacterial vegetations.
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