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Abstract #2436

Analysis and Design of Higher-Order Motion-Compensated Diffusion Encoding Schemes for In Vivo Cardiac DTI

Christopher Lee Welsh 1,2 , Edward VR DiBella 2 , and Edward W Hsu 1

1 Department of Bioengineering, University of Utah, Salt Lake City, UT, United States, 2 Radiology, UCAIR, University of Utah, Salt Lake City, UT, United States

Diffusion tensor imaging of the beating heart is technically challenging and remains elusive in some small animals due to the speed and scale of motion compared to the available gradient hardware performance. The current study performed a systematic analysis of the effects of cardiac motion on diffusion encoding and designed means to minimize them via higher-order motion compensation. Experimental testing showed that nulling of gradient moments associated with up to acceleration offered the best tradeoff among diffusion encoding level, motion artifact reduction, and image SNR. These efforts led to the first successful myocardial fiber orientation maps obtained in live rats.

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