Analysis and Design of Higher-Order Motion-Compensated Diffusion Encoding Schemes for In Vivo Cardiac DTI
Christopher Lee Welsh 1,2 , Edward VR DiBella 2 , and Edward W Hsu 1
Department of Bioengineering, University of
Utah, Salt Lake City, UT, United States,
UCAIR, University of Utah, Salt Lake City, UT, United
Diffusion tensor imaging of the beating heart is
technically challenging and remains elusive in some
small animals due to the speed and scale of motion
compared to the available gradient hardware performance.
The current study performed a systematic analysis of the
effects of cardiac motion on diffusion encoding and
designed means to minimize them via higher-order motion
compensation. Experimental testing showed that nulling
of gradient moments associated with up to acceleration
offered the best tradeoff among diffusion encoding
level, motion artifact reduction, and image SNR. These
efforts led to the first successful myocardial fiber
orientation maps obtained in live rats.
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