Abstract #2437
Detailing Myocardial Microstructure in the Ex Vivo Rat Heart Using High Isotropic Spatial Resolution Susceptibility Weighted MRI and Quantitative Susceptibility Mapping
Till Huelnhagen 1 , Andreas Pohlmann 1 , Fabian Hezel 1 , Eva Peper 1 , Min-Chi Ku 1 , and Thoralf Niendorf 1,2
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max Delbrueck Center for Molecular Medicine (MDC),
Berlin, Germany,
2
Experimental
and Clinical Research Center, a joint cooperation
between the Charite Medical Faculty and the Max
Delbrueck Center, Berlin, Germany
Myocardial microstructure is pivotal for cardiac
function and provides important information about
(patho)physiological conditions of the heart. Ex vivo
histology and diffusion weighted imaging (DWI) are
commonly used to assess myocardial tissue
microstructure, but in vivo DWI of the heart remains
challenging due to cardiac and respiratory motion.
Encouraged by the recent progress in susceptibility
weighted MRI we have investigated the feasibility of
high resolution quantitative susceptibility mapping
(QSM) for assessment of myocardial microstructure in the
ex vivo rat heart at 9.4 T. Results suggest that QSM
might be a useful tool for examination of myocardial
microstructure.
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