Abstract #2452
Diffusion Tensor MRI of the remodeled living heart in multiple mechanical states: First experiments in a rat model of chronic myocardial infarction
Maelene Lohezic 1 , Remi Peyronnet 2 , Craig Lygate 1 , Peter Kohl 2,3 , and Jurgen E Schneider 1
1
Division of Cardiovascular Medicine,
Radcliffe Department of Medicine, University of Oxford,
Oxford, United Kingdom,
2
National
Heart and Lung Institute, Imperial College London,
London, United Kingdom,
3
Department
of Computer Science, University of Oxford, Oxford,
United Kingdom
Myocardial microstructure underpins cardiac function in
health and disease, and can be assessed by diffusion
tensor MRI (DTI) in a non-destructive manner and
throughout the cardiac cycle. Here, we investigate
changes in DTI parameters in the live, chronically
infarcted, rat heart in multiple mechanical states. In
the remote area, the apparent diffusion coefficient
increased, while the fractional anisotropy was similar
to healthy control, in both slack and contracture
states. Also, remodeling translated into an increase in
the proportion of right-handed fibers in the remote area
while disarray was observed in the infarct zone.
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