Abstract #2457
Detection and Validation of Localized Chronic Iron Deposition within Non-Reperfused Myocardial Infarctions
Avinash Kali 1,2 , Ivan Cokic 1 , Hsin-Jung Yang 1,2 , Richard Tang 1 , and Rohan Dharmakumar 1,3
1
Biomedical Imaging Research Institute,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States,
2
Bioengineering,
University of California, Los Angeles, CA, United
States,
3
Department
of Medicine, University of California, Los Angeles, CA,
United States
We investigated whether stagnant blood within
permanently occluded vasculature in non-reperfused
myocardial infarction (MI) could lead to chronic iron
deposition within MI territories. T2* maps and Late
Gadolinium Enhancement images were acquired from canines
subjected to permanent ligation of LAD at 7 days and 4
months post-MI. Relative to remote myocardium, 42.6% T2*
loss was observed within the MI territories at 7 days
post-MI, and 39.1% T2* loss was observed within the MI
territories at 4 months post-MI. Mean iron volume was
2.1% of the total LV at 7 days post-MI and 1.9% of the
total LV at 4 months post-MI. Chronic iron deposition
can occur in non-reperfused MIs.
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