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Abstract #2473

Wall shear stress quantification and reproducibility using variable VENC 4D phase contrast MRI in the aorta

Wouter V Potters 1 , Anders Nilsson 2 , Sandra van den Berg 1 , Ed vanBavel 3 , Karin Markenroth Bloch 4 , Freddy Sthlberg 2,5 , and Aart J Nederveen 1

1 Radiology, Academic Medical Center, Amsterdam, Netherlands, 2 Medical Radiation Physics, Lund University, Lund, Sweden, 3 Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands, 4 Philips Healthcare, Lund, Sweden, 5 Diagnostic Radiology, Lund University, Lund, Sweden

Wall shear stress (WSS) is the force exerted by the flowing blood on the endothelial cells. WSS has been correlated with endothelial function and wall thickness. Quantification of WSS from 4D phase contrast MRI (4DPC) can be performed in the aorta, but is challenging in the diastolic part of the heart cycle due to a low velocity to noise ratio (VNR). A variable VENC 4D PC-MRI (4DvPC) sequence can significantly improve the VNR in diastole. We compared WSS quantification between 4DPC and 4DvPC to see if the improved VNR will also improve the diastolic WSS quantification. Additionally we investigated the WSS reproducibility.

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