Identification of Systematic Differences Between Different Methods for Extracting Pulse Wave Velocity with 4D Flow MRI

The purpose of the present study was to evaluate different methods for extracting pulse wave velocity (PWV) from 4D MR velocity data. 6 different methods were implemented and were applied to estimate aortic PWV in 8 young and 8 older normal volunteers. All methods were capable of resolving age-related differences in aortic PWV. However, systematic and significant differences were observed between the methods. These findings indicate that care must be taken when interpreting PWV estimates obtained by different types of methods.

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