Abstract #2471
Pressure Gradient Measurement in the Coronary Artery Using View-Shared (VS) 4D PC-MRI: Towards Noninvasive Quantification of Fractional Flow Reserve
Zixin Deng 1,2 , Guoxi Xie 3 , Yi He 4 , Nan Zhang 4 , Yutaka Natsuaki 5 , Ning Jin 5 , Xiaoming Bi 5 , Jing An 6 , Xin Liu 3 , Zhaoqi Zhang 4 , Zhanming Fan 4 , Debiao Li 1,2 , and Zhaoyang Fan 1
1
Biomedical Imaging Research Institute (BIRI),
Cedars-Sinai Medical Center, Los Angeles, CA, United
States,
2
Department
of Bioengineering, UCLA, Los Angeles, California, United
States,
3
Shenzhen
Institutes of Advanced Technology, Chinese Academy of
Sciences, Shenzhen, China,
4
Department
of Radiology, Anzhen Hospital, Beijing, China,
5
MR
R&D, Siemens Healthcare, Los Angeles, California, United
States,
6
MR
Collaborations NE Asia, Siemens Healthcare, Beijing,
China
Fractional flow reserve (FFR) is a diagnostic tool to
determine the functional significance of a stenosis.
However, its an invasive procedure involving
catheterization and exposure to radiation. We proposed a
non-invasive technique to derive FFR using view sharing
(VS) 4D Phase-contrast (PC)-MRI. Image acquisition for
VS4D PC-MRI is limited to the quiescent phase and
end-expiration to avoid motion-induced errors to the
coronaries. In this study, we have shown that the
technique can provide accurate velocity measurements and
potentially reduce motion-induced errors. ΔP of healthy
volunteers were reported and further studies are
underway in stenosed coronary arteries of animals and
patients.
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