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Abstract #2471

Pressure Gradient Measurement in the Coronary Artery Using View-Shared (VS) 4D PC-MRI: Towards Noninvasive Quantification of Fractional Flow Reserve

Zixin Deng 1,2 , Guoxi Xie 3 , Yi He 4 , Nan Zhang 4 , Yutaka Natsuaki 5 , Ning Jin 5 , Xiaoming Bi 5 , Jing An 6 , Xin Liu 3 , Zhaoqi Zhang 4 , Zhanming Fan 4 , Debiao Li 1,2 , and Zhaoyang Fan 1

1 Biomedical Imaging Research Institute (BIRI), Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Department of Bioengineering, UCLA, Los Angeles, California, United States, 3 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 4 Department of Radiology, Anzhen Hospital, Beijing, China, 5 MR R&D, Siemens Healthcare, Los Angeles, California, United States, 6 MR Collaborations NE Asia, Siemens Healthcare, Beijing, China

Fractional flow reserve (FFR) is a diagnostic tool to determine the functional significance of a stenosis. However, its an invasive procedure involving catheterization and exposure to radiation. We proposed a non-invasive technique to derive FFR using view sharing (VS) 4D Phase-contrast (PC)-MRI. Image acquisition for VS4D PC-MRI is limited to the quiescent phase and end-expiration to avoid motion-induced errors to the coronaries. In this study, we have shown that the technique can provide accurate velocity measurements and potentially reduce motion-induced errors. ΔP of healthy volunteers were reported and further studies are underway in stenosed coronary arteries of animals and patients.

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