Abstract #2531
Voxel anisotropy in carotid MRI: impact on fibrous cap thickness and lipid-rich necrotic core size measurements of atherosclerotic plaques
Harm Nieuwstadt 1 , Zaid Kassar 1,2 , Aad van der Lugt 2 , Ton van der Steen 1,3 , Marcel Breeuwer 4,5 , and Frank Gijsen 1
1
Biomedical Engineering, Erasmus MC,
Rotterdam, Zuid-Holland, Netherlands,
2
Radiology,
Erasmus MC, Rotterdam, Zuid-Holland, Netherlands,
3
Imaging
Science and Technology, Delft University of Technology,
Delft, Zuid-Holland, Netherlands,
4
Philips
Healthcare, Best, Noord Brabant, Netherlands,
5
Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Noord Brabant, Netherlands
We employed MRI simulations to quantify the influence of
slice thickness (i.e. voxel anisotropy in the
slice-select direction) for carotid MRI of
atherosclerotic plaques. We simulated a clinically
applied 2D T1 weighted sequence and varied the slice
thickness. Five realistic 3D plaque models were created
from histological data. We found significant
improvements in FC thickness measurement error when
using thinner slices, but less to no improvements in
LRNC size measurements. Our study indicates that for
carotid MRI, the use of anisotropic voxels can be
permitted for specific applications. However, the use of
thinner slices improves minimum FC thickness
measurements.
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