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Abstract #2547

Probing energy metabolism in the ischemic rat heart with hyperpolarized 13C MRS

Hikari A. I. Yoshihara 1,2 , Jessica A. M. Bastiaansen 2,3 , Corinne Berthonneche 4 , Arnaud Comment 2,3 , and Juerg Schwitter 5

1 Division of Cardiology, Lausanne University Hospital, Lausanne, Switzerland, 2 Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 3 Institute of Physics of Biological Systems, Ecole Polytechnique Fdrale de Lausanne, Switzerland, 4 Cardiovascular Assessment Facility, Lausanne University Hospital, Switzerland, 5 Division of Cardiology and Cardiac MR Center, Lausanne University Hospital, Switzerland

An open-chest rat model of myocardial ischemia was adapted to study in real time, using hyperpolarized 13C MRS, the changes in cardiac metabolism associated with short 15 minute periods of ischemia. Immediately following ischemia, a decrease in the conversion of infused hyperpolarized pyruvate to bicarbonate was observed relative to its conversion to lactate, consistent with the expected decrease in pyruvate dehydrogenase activity and increase in lactate concentration. This study establishes an experimental platform for further studies with other hyperpolarized 13C metabolic probes.

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