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Abstract #2551

MRI Evaluation of Coronary Versus Systemic Endothelial Function in Healthy Subjects and Patients with Coronary Artery Disease

Rupa Krishnaswamy 1 , Gary Gerstenblith 1 , Sahar Soleimanifard 2 , Michael Schar 3 , Matthias Stuber 4 , and Robert G Weiss 5

1 Medicine, Johns Hopkins University, Baltimore, MD, United States, 2 Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 3 Radiology, Johns Hopkins University, Baltimore, MD, United States, 4 Radiology, Centre Hospitalier Univ Vaudois, Lausanne, Switzerland, Switzerland, 5 Medicine, Radiology, Johns Hopkins Univ, MD, United States

We have used non-invasive 3T MRI with isometric handgrip exercise (IHE) to evaluate endothelial function of two physiologically different vascular beds (coronary and systemic) in healthy subjects and patients with coronary artery disease (CAD). Using this methodology, endothelial-dependent response of coronary and systemic vasculature can be assessed in the same person, and sometimes within the same MRI acquisition. We have confirmed that coronary vasodilation does not occur in patients with CAD, and demonstrated that the internal mammary artery exhibits a greater degree of vasodilation with IHE than the right coronary artery in patients with CAD.

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