Abstract #2552
A comparison of two sequences for spectral imaging of 19 F-containing emulsions
Rik PM Moonen 1,2 , Gustav J Strijkers 1,2 , Abdallah Motaal 1,2 , Rolf Lamerichs 2,3 , Muhammed Yildirim 4 , Erica Aussems-Custers 2,3 , Holger Gruell 1,3 , Martijn Wolters 5 , Eline ME Kooi 5 , Christoph Jacoby 6 , Ulrich Flgel 6 , and Klaas Nicolay 1,2
1
Biomedical Engineering/Biomedical NMR,
Eindhoven University of Technology, Eindhoven,
Netherlands,
2
Center
for Imaging Research & Education (CIRE), Eindhoven,
Netherlands,
3
Philips
Research, Eindhoven, Netherlands,
4
Philips
Healthcare, Best, Netherlands,
5
Department
of Radiology, Maastricht University Medical Center (MUMC+),
Maastricht, Netherlands,
6
Institut
fr Molekulare Kardiologie, Heinrich-Heine-Universitt,
Dsseldorf, Germany
Two accelerated
19
F
MRI sequences, Multiple Chemical Shift Selective RARE (MCSS-RARE)
and Fluorine ultrafast Turbo Spectroscopic Imaging (FuTSI)
were compared for their ability to image multiple
19
F
resonances of perfluorocarbon (PFC) emulsions. MCSS-RARE
is spectrally selective, whereas FuTSI has a spectral
read-out. The MCSS-RARE sequence proved superior in
terms of scan speed and SNR. Both sequences enabled
spectral imaging of
19
F
resonances in liver and spleen of ApoE-/- mice injected
with PFOB emulsion, but failed to visualize PFOB
accumulation in plaques in vivo. Ex vivo MCSS-RARE
imaging did reveal
19
F
resonances at major plaque sites.
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