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Abstract #2616

Characterization of the gray matter in spinal cords of Long Evans shaker rats by double-pulsed-field gradient MRI

Debbie Anaby 1 , Darya Morozov 1 , Ian D. Duncan 2 , and Yoram Cohen 1,3

1 School of Chemistry, Tel Aviv University, Tel Aviv, Israel, 2 Department of Medical Sciences, University of Wisconsin-Madison, Wisconsin, United States, 3 Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

Conventional single-pulsed-field-gradient (s-PFG) methodologies are capable of faithfully depicting diffusion anisotropy in coherently ordered structures. However, microstructure is more difficult to characterize where macroscopic organization is absent. Double-PFG (d-PFG) MR methodologies were recently suggested as an alternative for studying microstructure in such cases. The spinal cords white matter (WM) of Long Evans shaker (les) rats, a dysmyelinated model, was recently studied by q-space MRI. Here, we characterize the spinal cords of les rats and their controls by d-PGSE, focusing on the gray matter (GM), in comparison with DTI. d-PFG clearly differentiates between three GM areas of the les spinal cord.

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