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Abstract #2615

Biexponential modeling of diffusion in stroma and epithelium of prostate tissue

Ned Charles 1 , Gary Cowin 2 , Nyoman Kurniawan 2 , and Roger Bourne 3

1 University of Sydney, Camperdown, NSW, Australia, 2 University of Queensland, Brisbane, QLD, Australia, 3 University of Sydney, Sydney, NSW, Australia

Multi b-value data from 80 micrometer voxels was acquired from fixed prostate tissue in a 16T microimaging system. Biexponential modeling demonstrated distinct regional variations in diffusion behavior that correlate with microscopic tissue structure features. Regions dense in glands have a higher proportion of the lower diffusivity component, and this component has lower diffusivity in the glandular regions than in regions of fibromuscular stroma. An increasing partial volume of low diffusivity epithelial cells, rather than higher cellularity, may explain the clinical observation of decreasing ADC as prostate cancer Gleason grade increases.

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