Abstract #2615
Biexponential modeling of diffusion in stroma and epithelium of prostate tissue
Ned Charles 1 , Gary Cowin 2 , Nyoman Kurniawan 2 , and Roger Bourne 3
1
University of Sydney, Camperdown, NSW,
Australia,
2
University
of Queensland, Brisbane, QLD, Australia,
3
University
of Sydney, Sydney, NSW, Australia
Multi b-value data from 80 micrometer voxels was
acquired from fixed prostate tissue in a 16T
microimaging system. Biexponential modeling demonstrated
distinct regional variations in diffusion behavior that
correlate with microscopic tissue structure features.
Regions dense in glands have a higher proportion of the
lower diffusivity component, and this component has
lower diffusivity in the glandular regions than in
regions of fibromuscular stroma. An increasing partial
volume of low diffusivity epithelial cells, rather than
higher cellularity, may explain the clinical
observation of decreasing ADC as prostate cancer Gleason
grade increases.
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