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Abstract #2618

An estimate of Gd-DOTA diffusivity in blood by direct NMR diffusion measurement of its hydrodynamic analogue Ga-DOTA

Christian Wieseotte 1,2 , Manfred Wagner 2 , and Laura Schreiber 1

1 Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany, 2 Max Planck Institute for Polymer Research, Mainz, Germany

The diffusivity of contrast agents in the human body is a fundamental property which is still a factor of uncertainty in many applications. The main reason is that due to the highly paramagnetic Gd 3+ ion, direct observations by means of nuclear magnetic resonance are not possible. This study pursues the approach of directly measuring the diffusion of the hydrodynamically analogue PET tracer Gd-DOTA in deuterated water. The diffusivity in blood plasma can be calculated by correcting for the higher solvent viscosity. We report a diffusivity of Ga-/Gd-DOTA in blood plasma at 310K of D = 2.92 (0.25)∙10 -10 m 2 s-1.

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