Abstract #2619
Undulating and crossing axons in the corpus callosum may explain the overestimation of axon diameters with ActiveAx
Tim B Dyrby 1 , Mark Burke 2 , Daniel C Alexander 3 , and Maurice Ptito 1,4
1
Danish Research Centre for Magnetic
Resonance, Copenhagen University Hospital Hvidovre,
Hvidovre, Denmark,
2
Departments
of Physiology and Biophysics, Howard University,
Washington, United States,
3
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
4
School
of Optometry, University of Montreal, Montreal, Canada
Axon diameter (AD) estimates from diffusion-weighted
imaging (DWI) is known being overestimated when compared
with electron microscopy (EM). Mean AD in ten regions
across the corpus callosum (CC) was obtained from
painstaking EM. The ADs from DWI using ActiveAx method
were found overestimated but similar AD contrast as with
EM was observed across CC. With classical histology,
undulating axons was observed throughout CC, and
crossing axons in genu also. Undulation leads to larger
cross-sectional area than straight axons hence AD
overestimation. This suggests that macroscopic features
as undulating axons can explain the overestimation we
observed from AD estimates using DWI.
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