Abstract #2621
Bayesian Estimation of the Axonal Diffusion Coefficients in Brain White Matter
Enrico Kaden 1 , Frithjof Kruggel 2 , and Daniel C. Alexander 1
1
Centre for Medical Image Computing,
University College London, London, United Kingdom,
2
Department
of Biomedical Engineering, University of California,
Irvine, Irvine, CA, United States
Diffusion MR imaging has enabled us to study the
geometry of white matter in the individual human brain
noninvasively. The present work aims to quantify the
voxel-averaged diffusion coefficients parallel to an
axon and perpendicular to it without any prior knowledge
about how the axons are oriented within a voxel because
the fiber orientation distribution is typically not
known in advance. The axonal water diffusivity reflects
the fiber microanatomy such as the axon diameter, the
myelination, and the interaxonal space.
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