Abstract #2622
What does non-exponential diffusion-weighted signal decay reveal about myocellular barriers?
John G Georgiadis 1,2 , Caroline G Tennyson 1 , Danchin D Chen 1 , Armen A Gharibans 1 , and Curtis L Johnson 1,2
1
Mechanical Science and Engineering,
University of Illinois at Urbana-Champaign, Urbana, IL,
United States,
2
Beckman
Institute, University of Illinois at Urbana-Champaign,
Urbana, IL, United States
The successful employment of DTI to assess muscle
quality in older adults in vivo hinges on connecting the
signal to muscle cytoarchitecture. Seeking to explore
the well-established anisotropy of the DTI metrics in
muscle, the diffusion-weighted signal decay along the
secondary and tertiary eigenvector tracts as a function
of b-value was measured in the vastus medialis muscle of
a single subject. We introduced a continuum myofiber
model and attributed the non-exponential signal decay
with b-value to the presence of myocellular diffusion
barriers. This behavior cannot be accounted by lumped
two-compartment models commonly considered in skeletal
muscle DTI.
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