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Abstract #2622

What does non-exponential diffusion-weighted signal decay reveal about myocellular barriers?

John G Georgiadis 1,2 , Caroline G Tennyson 1 , Danchin D Chen 1 , Armen A Gharibans 1 , and Curtis L Johnson 1,2

1 Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2 Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States

The successful employment of DTI to assess muscle quality in older adults in vivo hinges on connecting the signal to muscle cytoarchitecture. Seeking to explore the well-established anisotropy of the DTI metrics in muscle, the diffusion-weighted signal decay along the secondary and tertiary eigenvector tracts as a function of b-value was measured in the vastus medialis muscle of a single subject. We introduced a continuum myofiber model and attributed the non-exponential signal decay with b-value to the presence of myocellular diffusion barriers. This behavior cannot be accounted by lumped two-compartment models commonly considered in skeletal muscle DTI.

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