Abstract #2624
Microstructural characterisation of normal and malignant human prostate tissue with VERDICT-MRI
Eleftheria Panagiotaki 1 , Rachel W Chan 2 , Nikolaos Dikaios 2 , Hashim U Ahmed 3 , David Atkinson 2 , Shonit Punwani 2 , David J Hawkes 1 , and Daniel C Alexander 1
1
Centre for Medical Image Computing,
University College London, London, London, United
Kingdom,
2
Centre
for Medical Imaging, University College London, London,
United Kingdom,
3
Research
Department of Urology, Div of Surgery & Interventional
Sci, University College London, London, United Kingdom
This study utilised diffusion-weighted MRI to probe in
vivo the microstructure of benign and cancerous prostate
tissue non-invasively. For this purpose, a mathematical
model was employed to capture the Vascular,
Extracellular and Restricted DIffusion for Cytometry in
Tumours (VERDICT). We demonstrate the technique in
patients with prostate cancer of Gleason score 7 (3+4)
in the peripheral zone (all imaged before undergoing
biopsy). Experiments using the VERDICT model identified
a significant increase in vascular volume in the tumour
regions. The standard apparent diffusion coefficient
(ADC) and intravoxel incoherent motion (IVIM) models
failed to detect any significant differences between
benign and tumour areas.
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